About 5.20am today (Sunday 27 February 2022), emergency services were called to the Golden Highway, Cassilis, in the Upper Hunter, after reports two trucks were involved in a head-on collision.
The male driver of one of the trucks died at the scene and is yet to be formally identified.
Officers from The Hunter Valley Police District established a crime scene, which will be examined by specialist forensic police.
An investigation into the crash is underway and a report will be prepared for the information of the Coroner.
The Highway is closed in both directions.
Motorists are urged to avoid the area as delays are expected.