Just after 3.40am (Thursday 15 February 2024), emergency services were called to Foundry Street, Wickham, following reports of an industrial fire.
Fire and Rescue NSW are on scene and working to extinguish the blaze.
Officers from Newcastle City Police Area Command have established a crime scene and commenced inquiries into the incident.
The cause of the fire is unknown at this stage.
Localised traffic diversions are in place and motorist are urged to avoid the area.
As inquiries continue, anyone with information into the incident is urged to call police or Crime Stoppers on 1800 333 000.